A series of novel oxazolone derivatives (3f to 3j) were synthesized by refluxing equimolar quantity of acetyl glycine, substituted aromatic and hetero aromatic aldehyde in presence of acetic anhydride and sodium acetate .The synthesized compounds were screened for oral hypoglycemic activity by alloxan induced model in male Sprague dawley rats. All the compounds were effective except 3h as compared with standard glibenclamide. The results are statistically treated for its significance.
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